Qamar is married to seasoned actor and comedian Mohib Mirza.^[10] Qamar had known Mirza since her school days when she was doing English plays with veteran actor Rahat Kazmibut she officially met Mirza on the sets of Geo Entertainment's Bachay Mann Kay Sachay which she was directing and Mirza was hosting.^[4] In 2005, they decided to get married and since then they have co-starred in number of telefilms and drama serials, as on-screen couple.^[4]

Returning to Pakistan, Sheikh landed a job with Geo Television, where she directed and produced children talkshow Bachey Man Ke Sachey. In 2007, Aamina made her on-screen debut in Sharjil Baloch and Khalid Ahmed's telefilm, Gurmuch Singh ki Waseeyat. The film was based on Saadat Hassan Manto's novel, The Will of Gurmukh Singh.^[6] Set during the time of partition, is a story of Sheikh Sahab and his friendship with Gurmukh Singh, a revered elder of the neighborhood. In the wake of Partition Muslims - with the exception of Sheikh Sahib - are leaving a largely Sikh village. Sheikh Sahib is confident that as long as his friend Gurmukh Singh, is there no harm can come to him or his family. On the night of Eid, Gurmukh Singh passes away leaving instructions with his son, that sweets should be delivered to Sheikh Sahib's house as had been the tradition for decades. His wish is carried out in the morning but in an unexpected way. The telefilm was well received and caught the attention of drama addicts.^[4] Aamina first major serial's offer came soon after that with Wilco, the ISPR and 7th Sky Entertainment's joint venture, where Aamina portrayed a woman from Thardesert.

In 2008, had Sheikh rolling with three major telefilms, Aasmaan Chu Lay, Pachees Qadam Pe Maut and Baarish Mein Deewar. Sheikh played a rickshaw driver who's determined to become the soul breadwinner of the family, in Syed Ali Reza's Aasmaan Chu lay. Sheikh had to learn and drive a rickshaw on Karachi's busiest M.A.Jinnah road and Garden Area, with a massive camera attached to it and had to attract real passengers.^[7] In the same year Sheikh made her runaway debut with Rehana Saigol’s fashion show.^[4][8] She has done extensive print work for fashion/advertising labels/companies, such as Maria B, Deepak Perwani, Amir Adnan, Nomi Ansari, Niche Lifestyle, Khaadi, Teejays, The Men's Store, Fahad Hussayn,Hang Ten, Maheen Khan, Umbereen Sharmeen, Chinyere, Crossroads and Limited Edition. In the following year, she did her second photoshoot for Niche Lifestyle, with Popstar andactor Atif Aslam.^[9]

In 2010, Sheikh did Mehreen Jabbar's mega drama serial Daam and Haissam Hussain's Ishq Gumshuda. Both of which had huge cast and were received well by both the audiences and critics. Sheikh has three serials on-air these days, two of which are for Geo Entertainment and another for ARY Digital.